Yazar "Gürel, Büşra" için listeleme
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Beyin ekstrasellüler matriksinin nörodejenerasyondaki rolünün alzheimer fare modelinde araştırılması
Gürel, Büşra (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Alzheimer hastalığında (AD), sinaptik yanıt mekanizmalarının ve sinaptik bağlantı stabilitesinin hasar gördüğü bilinmektedir. Son yıllarda yapılan çalışmalar, nöron ve glialar tarafından üretilen bazı ekstrasellüler matriks ... -
Characterization of biological molecule–loaded nanostructures using circular dichroism and fourier transform infrared spectroscopy
Parlar, Ayhan; Kulabhusan, Prabir Kumar; Kurt, Hasan; Gürel, Büşra; Torabfam, Milad; Özata, Başak; Yüce, Meral (Taylor and Francis, 2021)Drug-loaded nanoparticles have many advantages in drug administration, which is an essential step for the impact of the drugs and their mechanism of action. Circular dichroism (CD) is a spectroscopy technique that measures ... -
Characterization of FcγRIa (CD64) as a ligand molecule for site-specific IgG1 capture: A side-by-side comparison with protein a
Çapkın, Eda; Kurt, Hasan; Gürel, Büşra; Bıçak, Dilan; Akgün Baş, Sibel; Dağlıkoca, Duygu Emine; Yüce, Meral (American Chemical Society, 2022)Fc γreceptors (FcγRs) are one of the structures that can initiate effector function for monoclonal antibodies. FcγRIa has the highest affinity toward IgG1-type monoclonal antibodies among all FcγRs. In this study, a ... -
Early stage alterations in CA1 extracellular region proteins indicate dysregulation of IL6 and iron homeostasis in the 5XFAD Alzheimer's disease mouse model
Gürel, Büşra; Cansev, Mehmet; Sevinç, Cansu; Keleştemur, Seda; Öcalan, Büşra; Çakır, Ayşen; Aydın, Sami; Kahveci, Nevzat; Ozansoy, Mehmet; Taşkapılıoğlu, Özlem; Ulus, İsmail Hakkı; Karayel Başar, Merve; Şahin, Betül; Tüzüner, Mete Bora; Baykal, Ahmet Tarık (Ios Press, 2018)In recent years, an increasing number of research papers revealed that the compositional and volumetric alterations in the extracellular matrix are the consequences of aging and may be related to Alzheimer's disease (AD). ... -
Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival
Yalçın, Esra; Beker, Mustafa Çağlar; Türkseven, Şeyma; Çağlayan, Berrak; Gürel, Büşra; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Kalkan, Rabia; Baykal, Ahmet Tarık; Keleştemur, Taha; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2019)Indolamine melatonin structurally resembles non-covalent proteasome inhibitors; however, the role of ubiquitin proteasome system (UPS) in neuronal survival and how melatonin carries out UPS inhibition remain largely unknown. ... -
Molecular signatures of chronic periodontitis in gingiva: A genomic and proteomic analysis
Güzeldemir Akçakanat, Esra; Alkan, Begüm; Sünnetçi Akkoyunlu, Deniz; Gürel, Büşra; Balta, Vecihe Merve; Kan, Bahadır; Akgün, Emel; Yılmaz, Elif Büşra; Tarık Baykal, Ahmet; Cine, Naci; Olgaç, Vakur; Gümüşlü, Esen; Savlı, Hakan (Wiley-Blackwell, 2019)Background: To elucidate molecular signatures of chronic periodontitis (CP) using gingival tissue samples through omics-based whole-genome transcriptomic and whole protein profiling. Methods: Gingival tissues from 18 CP ... -
Neonatal neurodegeneration in alzheimer's disease transgenic mouse model
Mazi, Aişe Rümeysa; Arzuman, Ayşegül Sümeyye; Gürel, Büşra; Şahin, Betül; Tüzüner, Mete Bora; Ozansoy, Mehmet; Baykal, Ahmet Tarık (IOS Press, 2018)Alzheimer's disease (AD) is a progressive disorder characterized by a variety of molecular pathologies causing cortical dementia with a prominent memory deficit. Formation of the pathology, which begins decades before the ... -
Proteomics analysis of CA1 region of the hippocampus in pre-, progression and pathological stages in a mouse model of the alzheimer’s disease
Gürel, Büşra; Cansev, Mehmet; Koç, Cansu; Öcalan, Büşra; Çakır, Aysen; Aydın, Sami; Kahveci, Nevzat; Ulus, İsmail Hakkı; Şahin, Betül; Başar, Merve Karayel; Baykal, Ahmet Tarık (Bentham Science Publishers, 2019)Background: CA1 subregion of the hippocampal formation is one of the primarily affected structures in AD, yet not much is known about proteome alterations in the extracellular milieu of this region. Objective: In this ... -
Time-of-day dependent neuronal injury after ischemic stroke: Implication of circadian clock transcriptional factor bmal1 and survival kinase akt
Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Ahmet Burak; Türkseven, Şeyma; Gürel, Büşra; Keleştemur, Taha; Sertel, Elif; Şahin, Zafer; Kutlu, Selim; Kılıç, Ülkan; Baykal, Ahmet Tarık; Kılıç, Ertuğrul (Humana Press Inc, 2018)Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained ...